Contribution of skeletal muscle-specific microRNA to insulin resistance in heart failure

Exercise intolerance (EI) and insulin resistance (IR) are hallmarks of heart failure (HF). Abnormalities in skeletal muscle metabolism, where glucose is a major energy source, have been identified in HF and may be a link between EI and IR but the underlying mechanisms are poorly understood. Overall design: Comparative miRNA expression profiling analysis of RNA-seq data for skeletal muscle of mice with HF induced by transverse aortic constriction (TAC)