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Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion Positive Prostate Cancer

ChEBI2011-05-18 更新2026-07-21 收录

PARP抑制剂机制

ETS融合阳性前列腺癌

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-27723 数据链接链接失效反馈

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Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion Positive Prostate Cancer

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创建时间：

2011-05-18

PARP抑制剂机制

药物靶点复合物

PARP15 catalytic domain in complex with OUL218 Descriptor: 4-(1,3-thiazol-5-ylmethoxy)benzamide, DIMETHYL SULFOXIDE, Protein mono-ADP-ribosyltransferase PARP15 Authors: Maksimainen, M.M, Murthy, S, Le

Protein Data Bank Japan2024-01-31 更新80

PJ34- and ABT888-induced reduction of PARs influences histone H3 and H4 acetylation.

组蛋白乙酰化

PARP抑制剂机制

(A) Representative Western blot of whole cell extracts from cells treated with the inhibitor PJ34 (5μM) at the indicated times relative to untreated cells (NT, value ~1), run on a 15% SDS-PAGE, and pr

NIAID Data Ecosystem70

Gene expression profilings for prostate cancer cells after inhibition of PARP1 or PARP2 using pharmaceutical or siRNA-based approaches

前列腺癌治疗

PARP抑制剂机制

Androgen receptor (AR) signaling is a key driver of prostate cancer (PCa) growth and progression. Understanding the factors influencing AR-mediated transcription provides new opportunities for therape

NIAID Data Ecosystem30

Uncoupling of PARP1 Trapping and Inhibition Using Selective PARP1 Degradation

PARP抑制剂机制

靶向蛋白质降解药物

PARP1 inhibitors (PARPi) are known to kill tumor cells via two mechanisms (i.e., PARP1 catalytic inhibition vs. PARP1 trapping). The relative contribution of these two pathways in mediating the cytoto

NIAID Data Ecosystem70

Effect of PARP1 inhibition on transcription high and low PARP activity cell lines. Homo sapiens

PARP抑制剂机制

癌细胞转录组

Analysis of the role of PARP1 in gene transcription in cell lines with variable PARP1 activity. Overall design: Total RNA was collected from MCF7, KPL-1, ZR7530, T47D, SKBR3, and Hs578T cells that had

NIAID Data Ecosystem50

Mechanistic Rationale for Inhibition of Poly(ADP-Ribose) Polymerase in ETS Gene Fusion Positive Prostate Cancer

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