Somatic mutations and V_H-gene distance of MAbs grouped according to short (< = 13aa), medium (14-18 aa) or long (> = 19aa) CDR-H3 length.

aMAbs are categorized by Ag type and condition: Nt, broadly neutralizing; NP, non-protein; P, protein; SAD, autoimmune disease; ChI, chronic infection; AcI, acute infection and vaccination; Self = SAD MAbs; non-Self = ChI plus AcI MAbs. bDistance between an Ab's germline VH gene and the VH6-1 gene, the VH gene closest to the DH region. cNA, Not available; i.e., there were no MAbs of this type in the database. dSample sizes<25 are given in parentheses.