Molecular bases of regulation of cardiac contractility
收藏ESRF Portal2028-01-01 更新2026-04-23 收录
下载链接：
https://doi.esrf.fr/10.15151/ESRF-ES-2228237518
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资源简介：
Regulation of heart contractility is operated by both thin, actin containing filaments, and thick, myosin containing filaments. Ca2+-induced structural changes in the regulatory proteins of the thin filament release the actin sites for interaction with myosin motors. Thick filament mechanosensing adapts to the load the number of motors recruited from the OFF state in which they lie tilted back on their tails unable to interact with actin. In the heartbeat both thin and thick filament activations are under the control of modulatory mechanisms by accessory proteins. Mutations in these proteins cause dysregulation and cardiomyopathy. We use sarcomere-level mechanics and X-ray diffraction on intact and demembranated myocytes of the ventricle of wild type, mutant and transgenic animal models to investigate the mechanisms that control thick filament regulation/dysregulation and test small molecules candidate as therapeutic tools.
提供机构：
University of Florence, Physiolab, via Sansone 1, 50019 Sesto Fiorentino, Italy; Universita degli Studi di Firenze, Dipartimento di Biologia, Via Madonna del Piano 6, 50019 Sesto Fiorentino, Italy; University of Florence, Via Madonna del Piano, 6, Sesto Fiorentino, 50019 Firenze, Italy
创建时间：
2028-01-01
