Transcriptional Inactivation of TP53 and BMP Pathway Components Mediates Therapy-induced Dedifferentiation and Metastasis in Prostate Cancer (ATAC-seq)
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE162227
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资源简介：
AR blockade instigates two separate and complementary processes: 1) transcriptional silencing of TP53 and hence acquisition of hybrid E/M and stem-like traits; and 2) inhibition of the BMP signaling, which promotes resistance to the pro-apoptotic and anti-proliferative effects of AR inhibition. The drug tolerant prostate cancer cells generated through reprogramming are rescued by neuregulin and generate metastases in mice. Bulk ATAC sequencing of the samples from various time points over the course of enzalutamide treatment of human prostate adenocarcinoma cells LNCaP.
创建时间：
2022-04-21
