Interactions confidence measured by Class scores used to represent different edge widths in the networks.

1Parameters used to calculate the Class scores: interaction described as experimental (not predicted) (+4); interaction described in more than one paper (PubMed ID >1) and at least one paper not describing high-throughput (HT) experiments (+4); interaction described in more than one paper (PubMed ID >1) (+3); interaction described in only one paper (PubMed ID  = 1) (+1); interacting nodes described in the same cellular component (CC) (+1). For novel interactions not described in any paper (PubMed ID  = 0), even if the interacting nodes are described in the same CC, it will be assigned Class score E.