Synthesis of Spiro[oxindole-3,2′-pyrrolidine] Derivatives from Benzynes and Azomethine Ylides through 1,3-Dipolar Cycloaddition Reactions
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https://figshare.com/articles/dataset/Synthesis_of_Spiro_oxindole-3_2_-pyrrolidine_Derivatives_from_Benzynes_and_Azomethine_Ylides_through_1_3-Dipolar_Cycloaddition_Reactions/7271225
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资源简介：
A novel
synthetic strategy employing benzyne and azomethine ylides
for the construction of spiro[oxindole-3,2′-pyrrolidine] derivatives
has been achieved in good yields. The ketimines obtained from the
condensation of isatins with CF3CH2NH2 react with benzyne in the presence of weak bases such as TBAF or
TBAT. This mild practical 1,3-dipolar cycloaddition provides an efficient
route to access biologically active compounds.
创建时间：
2018-10-30
