Crystal structure of BTK kinase domain complexed with 2-Methyl-5-[(E)-(3-phenyl-acryloyl)amino]-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-benzamide

Crystal structure of BTK kinase domain complexed with 2-Methyl-5-[(E)-(3-phenyl-acryloyl)amino]-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-benzamide Descriptor: 2-methyl-N-(2-phenyl-3H-imidazo[4,5-b]pyridin-6-yl)-5-{[(2E)-3-phenylprop-2-enoyl]amino}benzamide, Tyrosine-protein kinase BTK Authors: Kuglstatter, A, Wong, A. Deposit date: 2010-11-08 Release date: 2011-01-12 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.85 Å) Cite: Insights into the conformational flexibility of Bruton's tyrosine kinase from multiple ligand complex structures. Protein Sci., 20, 2011

布鲁顿酪氨酸激酶（BTK）激酶结构域与2-甲基-5-[(E)-(3-苯基丙烯酰基)氨基]-N-(2-苯基-3H-咪唑并[4,5-b]吡啶-6-基)苯甲酰胺形成的复合物的晶体结构。配体描述：2-甲基-N-(2-苯基-3H-咪唑并[4,5-b]吡啶-6-基)-5-{[(2E)-3-苯基丙-2-烯酰基]氨基}苯甲酰胺，酪氨酸蛋白激酶BTK。作者：Kuglstatter, A、Wong, A. 存入日期：2010-11-08，发布日期：2011-01-12，最后修改日期：2023-09-06。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.85 Å）。引用文献：从多种配体复合物结构解析布鲁顿酪氨酸激酶的构象灵活性，Protein Sci.，20卷，2011年。