In this study we tested the hypothesis that pregnancy, a physiologic condition of transient, organ system-based immune evasion, can integrate known and identify new mechanisms of immune modulation per
To understand the role of RON in malignant behaviors of bladder cancer cells in more detail, we applied the cellular mRNA expression profiling method to 5637-shRON and 5637-NC cells to determine any e
Purinostat Mesylate (PM), a highly selective HDAC I/IIb inhibitor, exhibits excellent antitumor activity in multiple MM and lymphoma cell lines and multiple mouse models, outperforming the pan-HDAC in
Polycomb Repressive Complex 2 (PRC2) is an epigenetic regulator induced in many cancers. It is thought to drive tumorigenesis by repressing division, stemness, and/or developmental regulators. Cancers
The maintenance of quiescence is essential for tissue homeostasis. STAG2 is one of the few genes mutated in the normal urothelium of organ donors, with mutant cells undergoing positive selection 1. ST
