Yap Promotes Outbound Noncanonical Wnt Signaling from Cardiomyocytes to Fibroblast to Enhance Neonatal Heart Regeneration. Yap Promotes Outbound Noncanonical Wnt Signaling from Cardiomyocytes to Fibroblast to Enhance Neonatal Heart Regeneration

We used Bulk RNA sequencing to determine the global transcriptional effects of Wls cKO in cardiomyocytes on mouse injury response after MI. Overall design: Cardiomyocytes and Non-Cardiomyocytes were collected from each mice. Each mice received three consecutive doses of TAM from P1-P3, and mice underwent MI at P2. Samples were collected 2 weeks are surgery. 3 Hearts were collected from each experimental condition.