Institut Pasteur BAG - Structural biology of infectious agents

The Institut Pasteur’s BAG gathers the projects of the research units and platforms of the Institut Pasteur in Paris which are active in the structural biology field: Structural Microbiology (P.M. Alzari), Structural Dynamics of Macromolecules (M. Delarue), Structural Virology (F. Rey) and the Platform of Crystallography (A. Haouz). The non-exhaustive list of ongoing projects includes: - actinobacterial SepF, FtsZ and other cell division proteins; - central metabolic enzymes from actinobacteria; - DNA gyrase from Mycobacterium tuberculosis or model organisms; - Plasmodium proteases as drug targets; - bacterial models of pentameric ligand-gated ion channel family (pLGIC) receptors; - eukaryotic and archeal DNA polymerases and replisome proteins; - viral envelope proteins from pathogenic viruses, and their complexes with neutralizing antibodies; - enzymes and structural proteins from other human pathogens, supported by evolving national and international collaborations.