The RNA content of plasma-derived extracellular vesicles in cerebral malaria

We sequenced the RNA content of circulating extracellular vesicles obtained from retinopathy- positive (CM-R⁺) and negative cerebral malaria (CM-R⁻) patients and community controls (CC) without Plasmodium falciparum infection. We found that some of the transcripts enriched in circulating extracellular vesicles are highly expressed in the brain compared to other tissues and could have a diagnostic potential in the cerebral malaria context. To investigate the biological content of extracellular vesicles obtained from the plasma of cerebral malaria patients and community healthy controls without Plasmodium falciparum infection.