Native ECM in obesity visceral adipose tissue initiates human adipose stem cell senescence via TGF-beta and mitochondrial signaling

Background & Aims: Obesity is a complex disease that causes visceral WAT dysfunction and is associated with cardiovascular, chronic inflammatory and other metabolic pathologies.Adipose-derived stem cells (ASCs) are the key cells for adipose tissue homeostasis.However, how obesity may affect the biological functions of hASCs is not clear. We then performed gene expression profiling analysis using data obtained from RNA-seq of 8 different donors obese group,and 3 different donors lean group Overall design: Comparative gene expression profiling analysis of RNA-seq data for 8 different donors obese group, and 3 different donors lean group