Summary of exhaustive haplotype analyses based on sex-adjusted omnibus tests for sliding windows of all possible sizes across 16 SNPs under study for subjects of Group 1.^a

aExhaustive haplotype analyses were performed using sliding windows (SW) of all possible sizes (i.e. number of SNPs per SW; 1 to 16 SNPs per SW) with PLINK. With logistic regression, a single case-control omnibus test of (H - 1) degrees of freedom was carried out for each sliding window to jointly assess the significance of the haplotype effects for this SW and adjusted for sex (as a covariate), where H is the number of haplotypes for the SW under consideration. Here, a single asymptotic P value (Pasym) was produced for each SW. For a given window size, the test was performed for all possible windows of the same size, shifting one SNP at a time. There were a total of 136 windows (the sum of numbers in column 2), and multiple comparisons were corrected by running 50,000 permutations to obtain an empirical P value (Pemp). The minimum P value that is achievable with 50,000 permutations is 2.00×10−5. The SW is indicated as Sa..Sb, where a is the first SNP and b the last SNP of the SW. For example, S4..S7 refers to the SW S4-S5-S6-S7. The three rightmost columns show the most significant results for each fixed-size SW. Note that, among all 136 windows tested, S4..S7 ranks the first and S5..S7 the second in providing evidence for association with high myopia.