Effects of Fecal Microbiome Transplantation (FMT) on Growth, Gut Microbiota, and Gene Expression in DBA Mice

Numerous studies have demonstrated that C57BL/6 mice exhibit superior growth rates and overall growth performance compared to DBA mice. To investigate whether this discrepancy in growth performance is linked to the composition of gut microorganisms, we conducted fecal microbiome transplantation (FMT) experiments. Specifically, we transplanted fecal fluids from adult C57BL/6 mice, high-fat C57BL/6 mice, and Wistar rats into weaned DBA mice, and subsequently analyzed their gut contents and gene expression through 16S rRNA sequencing and transcriptome sequensing.