Comparative quantitative proteomic and S-nitrosoproteomic profiling of iWAT from WT and GSNOR KI mice.

To elucidate the potential mechanisms of GSNOR in age-related obesity, we performed protein quantitative proteomics and quantitative S-nitrosation proteomics to investigate the levels and sites of protein S-nitrosation in iWAT from control and GSNOR KI mice为阐明S-亚硝基谷胱甘肽还原酶（GSNOR）在衰老相关性肥胖中的潜在作用机制，本研究开展了蛋白质定量蛋白质组学与定量S-亚硝基化蛋白质组学实验，以探究对照组与GSNOR敲入（KI）小鼠的腹股沟白色脂肪组织（inguinal white adipose tissue, iWAT）中蛋白质S-亚硝基化的水平与修饰位点。