Mechanistic elucidation of human pancreatic acinar development using single cell transcriptome analysis on a human iPSC differentiation model

To elucidate the differentiation mechanisms of pancreatic acinar lineages, we performed single-cell RNA-seq analysis on the grafts obtained by implanting human iPSC-derived pancreatic endoderm cells into NOD-SCID mice. We then performed single cell transcriptome analysis using data obtained from single-cell RNA-seq of the 3 samples. Overall design: Single cell transcriptome analysis of single-cell RNA-seq data for 585A1 cell line-derived pancreatic endoderm cells and the grafts obtained by implanting human iPSC-derived pancreatic endoderm cells into NOD-SCID mice.