A Retinoic Acid-dependent Stroma-Leukemia Crosstalk Promotes Chronic Lymphocytic Leukemia Progression [RNA-seq]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE111612
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资源简介：
In B-cell chronic lymphocytic leukemia (CLL), the non-hematopoietic stromal microenvironment plays a critical role in promoting tumor cell recruitment, activation, survival and expansion. Using the Eμ-TCL1 mouse model, we demonstrate that leukemic cells induce the activation of retinoid acid synthesis and signaling in stromal cells of the lymphoid microenvironment. Four stromal samples treated with vehicle (DMSO) and four stromal samples treated with BMS493
创建时间：
2019-03-21
