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Therapeutic decoupling of MHC-I and PD-L1 expression increases the efficacy of immune checkpoint blockade

NIAID Data Ecosystem2026-03-12 收录

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MHC-I/PD-L1表达调控

数据链接：

https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE149826 数据链接链接失效反馈

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资源简介：

This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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创建时间：

2021-08-06

分枝杆菌感染免疫

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The murine immune response to a pulmonary mycobacterial infection is slow to develop, allowing bacterial numbers to increase in the lung for several weeks after infection. We sought to enhance the pro

PubMed Central80

Additional file 5 of Clonal tracing reveals diverse patterns of response to immune checkpoint blockade

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转录调控

Additional file 5: Table S4. LISA inference of transcription regulators that may best account for the differentially expressed genes.

Figshare2024-03-04 更新50

Paired VDJ and transcriptome single cell sequencing in LMP2 multimer-positive human T cells treated with anti-PD-L1 and anti-TIM3 antibodies.

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单细胞测序

We report the change in gene expression profile paired to clonotype profiling in single cells from LMP2 multimer-positive human T cells generated following weekly stimulations with antigen-pulsed dend

NIAID Data Ecosystem30

Blocking experiment CD83 and PD-1

细胞共培养

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Co-culture of dendritic cells and T cells with or without blocking antibodies against CD83 or PD-1.

NIAID Data Ecosystem70

Synergistic Reversal of Intrahepatic HCV-Specific CD8 T Cell Exhaustion by Combined PD-1/CTLA-4 Blockade

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慢性病毒感染免疫

Viral persistence is associated with hierarchical antiviral CD8 T cell exhaustion with increased programmed death-1 (PD-1) expression. In HCV persistence, HCV-specific CD8 T cells from the liver (the

NIAID Data Ecosystem50

Therapeutic decoupling of MHC-I and PD-L1 expression increases the efficacy of immune checkpoint blockade

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