Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with Chromone 5d
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Crystal structure of stabilized A2A adenosine receptor A2AR-StaR2-bRIL in complex with Chromone 5d Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Adenosine receptor A2a,Soluble cytochrome b562,Adenosine receptor A2a, ... Authors: Verdon, G, Jespers, W, Azuaje, J, Majellaro, M, Keranen, H, Garcia-mera, X, Congreve, M, Deflorian, F, de Graaf, C, Zhukov, A, Dore, A, Mason, J, Aqvist, J, Cooke, R, Sotelo, E, Gutierrez-de-Teran, H. Deposit date: 2020-06-15 Release date: 2020-09-16 Last modified: 2024-10-23 Method: X-RAY DIFFRACTION (2.13 Å) Cite: X-Ray Crystallography and Free Energy Calculations Reveal the Binding Mechanism of A 2A Adenosine Receptor Antagonists. Angew.Chem.Int.Ed.Engl., 59, 2020
稳定化A₂A腺苷受体（A2A adenosine receptor）变体A2AR-StaR2-bRIL与色酮5d结合的晶体结构。复合物组分：(2R)-2,3-二羟基丙基(9Z)-十八碳-9-烯酸酯、(2S)-2,3-二羟基丙基(9Z)-十八碳-9-烯酸酯、腺苷受体A2a、可溶性细胞色素b562、腺苷受体A2a……。作者：Verdon G、Jespers W、Azuaje J、Majellaro M、Keranen H、Garcia-mera X、Congreve M、Deflorian F、de Graaf C、Zhukov A、Dore A、Mason J、Aqvist J、Cooke R、Sotelo E、Gutierrez-de-Teran H。沉积日期：2020-06-15，发布日期：2020-09-16，最后修改日期：2024-10-23。实验方法：X射线衍射（分辨率2.13埃）。引用文献：X射线晶体学与自由能计算揭示A₂A腺苷受体拮抗剂的结合机制，Angew.Chem.Int.Ed.Engl.，第59卷，2020年
创建时间：
2020-06-15
