Effect of B cell receptor class-switching on WSU-FSCCL lymphoma cells
收藏NIAID Data Ecosystem2026-05-02 收录
下载链接：
https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE267440
下载链接
链接失效反馈官方服务：
资源简介：
Although immunoglobulin class-switching from IgM to IgG enhances B cell receptor (BCR) signalling and antibody responses, certain subsets of B cell lymphomas retain unswitched IgM BCRs despite signs of class-switching in the immunoglobulin heavy chain loci. This suggests that expression of the IgG BCR suppresses progression of specific lymphoma subsets. We found that inducing BCR class switching from IgM to IgG1 or IgG4 inhibits proliferation of B EZB DLBCL lymphoma cell lines. To understand changes associated with class-switching we compared transcritional profiles of isogenic WSU-FSCCL cell lines artificially class-switched to express IgM and IgG BCRs. RNASeq was performed on WSU-FSCCL IgM+ and WSU-FSCCL IgG4+ cells sorted after CRISPR-induced immunoglobulin class-switching. --------------------------------------------------------------------------------------- Two samples were removed from this series on August 29, 2025 due to strong batch effect. ---------------------------------------------------------------------------------------
创建时间：
2025-08-29
