Co-crystal Structure of PERK with 2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide inhibitor

Co-crystal Structure of PERK with 2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide inhibitor Descriptor: 2-amino-N-[4-methoxy-3-(trifluoromethyl)phenyl]-4-methyl-3-[2-(methylamino)quinazolin-6-yl]benzamide, Eukaryotic translation initiation factor 2-alpha kinase 3,Eukaryotic translation initiation factor 2-alpha kinase 3, L(+)-TARTARIC ACID Authors: Shaffer, P.L, Long, A.M, Chen, H. Deposit date: 2014-12-09 Release date: 2015-01-28 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Discovery of 1H-Pyrazol-3(2H)-ones as Potent and Selective Inhibitors of Protein Kinase R-like Endoplasmic Reticulum Kinase (PERK). J.Med.Chem., 58, 2015

PERK与2-氨基-N-[4-甲氧基-3-(三氟甲基)苯基]-4-甲基-3-[2-(甲氨基)喹唑啉-6-基]苯甲酰胺抑制剂的共晶体结构
描述物：2-氨基-N-[4-甲氧基-3-(三氟甲基)苯基]-4-甲基-3-[2-(甲氨基)喹唑啉-6-基]苯甲酰胺、真核翻译起始因子2α激酶3（Eukaryotic translation initiation factor 2-alpha kinase 3）、真核翻译起始因子2α激酶3、L(+)-酒石酸
作者：Shaffer, P.L.、Long, A.M.、Chen, H.
提交日期：2014-12-09
发布日期：2015-01-28
末次修改日期：2023-09-27
实验方法：X射线衍射（2.3 Å）
引用文献：《1H-吡唑-3(2H)-酮类作为蛋白激酶R样内质网激酶（PERK）强效选择性抑制剂的发现》，J.Med.Chem., 58, 2015