IGF2BP1 is a targetable SRC/MAPK-dependent driver of invasive growth in ovarian cancer
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https://www.ncbi.nlm.nih.gov/sra/SRP255013
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We identified IGF2BP1 as a marker of the C5 molecular subtype of high-grade ovarian carcinoma (HG-SOC). IGF2BP1 promotes SRC activity and ERK2 expression enhancing the tolerance towards SRC- and MEK-directed inhibitors saracatinib and selumetib. Combination treatment overcomes IGF2BP1-promoted resistance. Overall design: PolyA-RNA sequencing of tumor samples was performed to investigate correlation of IGF2BP1 to molecular signatures and identify the molecular subtypes of the respective tumor samples.
创建时间：
2020-11-26
