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Analysis of TC-mAb mice (Exp6: Plasma cell)

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The experiment had been performed to analyze B cell development of human antibody-procducing mice (TC-mAb mice). The flow cytometry experiment was designed to detect the subsets of plasmablasts/plasma cells (CD138+TACI+) in the spleen of unimmunized and immunized approximately 21 weeks-old mice. Notes: This experiment corresponds to Supplementary Figure 9b and Supplementary Figure 38-39 in the paper "Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci". Publication link: https://doi.org/10.21203/rs.3.rs-103241/v1
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2022-03-01
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