Identification of spatially-resolved markers of malignant transformation in Intraductal Papillary Mucinous Neoplasms. [Visium]

Spatial transcriptomics characterization of IPMN samples by Visium Gene Expression FFPE We performed Visium spatial transcriptomics in TMA cohorts of IPMN samples grouped by morphology and degree of dysplasia : 18 samples from 14 patients: 4 low-grade IPMN (3 low-grade dysplasia (LGD), 1 intermediate dysplasia/Borderline), 9 high-grade IPMN characterized by a high-grade of dysplasia (HGD), including 4 invasive IPMN with associated PDAC, and 1 PDAC-associated normal duct).