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Synthesis of 4‑Sulfenyl Isoxazoles through AlCl3‑Mediated Electrophilic Cyclization and Sulfenylation of 2‑Alkyn-1-one O‑Methyloximes

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Figshare2019-03-21 更新2026-04-29 收录
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An efficient method for the synthesis of 4-sulfenyl isoxazoles has been developed via AlCl3-mediated electrophilic cyclization/sulfenylation of 2-alkyn-1-one O-methyloximes. Remarkably, N-arylsulfanylsuccinimides are employed as electrophiles for the construction of 4-arylsulfanyl isoxazoles, and 4-alkylsulfanyl isoxazoles are accessed with dialkyl disulfides as electrophiles.

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2019-03-21
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