Antigen modifications improve mRNA-based influenza virus vaccines

Nucleoside-modified, lipid nanoparticle-encapsulated mRNAs have recently emerged as suitable vaccines for influenza viruses and other pathogens in part because the platform allows delivery of multiple antigens in a single immunization. mRNA vaccines allow for easy antigen modification, enabling rapid iterative design. Here, we studied protein modifications which could improve the safety and/or potency of mRNA-based influenza virus vaccines.