Cathepsin H: A Target Enabling Package

CTSH participates in multiple AD linked biological domains, as noted above, and plays a role in both proteostasis and apoptosis, as well as immune response–three biological domains linked with AD pathology.  Little is known about the precise role that CTSH may play in AD pathology, but it participates in hypotheses linked with all three biological domains.  Given the genetic and omic association with AD risk, elucidating the mechanisms of biological contribution to AD risk may inform future therapeutic development.  The goal of this project is to develop a basic target enabling package to facilitate the future exploration of the role of CTSH in AD biology.