Estrogen Receptor Alpha Ligand Binding Domain in Complex with (1'-(4-(2-(ethylamino)ethoxy)phenyl)-6'-hydroxy-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone

Estrogen Receptor Alpha Ligand Binding Domain in Complex with (1'-(4-(2-(ethylamino)ethoxy)phenyl)-6'-hydroxy-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl)(phenyl)methanone Descriptor: Estrogen receptor, [(1'R)-1'-{4-[2-(ethylamino)ethoxy]phenyl}-6'-hydroxy-1',4'-dihydro-2'H-spiro[cyclopropane-1,3'-isoquinolin]-2'-yl](phenyl)methanone Authors: Hancock, G.R, Young, K.S, Hosfield, D.J, Joiner, C, Sullivan, E.A, Yildz, Y, Laine, M, Greene, G.L, Fanning, S.W. Deposit date: 2022-07-27 Release date: 2022-11-09 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Unconventional isoquinoline-based SERMs elicit fulvestrant-like transcriptional programs in ER+ breast cancer cells. NPJ Breast Cancer, 8, 2022

雌激素受体α配体结合域（Estrogen Receptor Alpha Ligand Binding Domain）与(1'-(4-(2-(乙氨基)乙氧基)苯基)-6'-羟基-1',4'-二氢-2'H-螺[环丙烷-1,3'-异喹啉]-2'-基)(苯基)甲酮的复合物
描述项：雌激素受体（Estrogen Receptor），[(1'R)-1'-{4-[2-(乙氨基)乙氧基]苯基}-6'-羟基-1',4'-二氢-2'H-螺[环丙烷-1,3'-异喹啉]-2'-基](苯基)甲酮
作者：Hancock, G.R、Young, K.S、Hosfield, D.J、Joiner, C、Sullivan, E.A、Yildz, Y、Laine, M、Greene, G.L、Fanning, S.W.
提交日期：2022-07-27
发布日期：2022-11-09
最后修改日期：2023-10-25
实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.9埃（Å）
引用文献：基于异喹啉的非经典选择性雌激素受体调节剂（Selective Estrogen Receptor Modulators, SERMs）可在ER阳性（ER+）乳腺癌细胞中诱导类似氟维司群的转录程序。《NPJ乳腺癌》（NPJ Breast Cancer），第8卷，2022年