Chromatin binding protein PHF6 regulates activity-dependent transcription networks to promote hunger response [RNA-Seq]

We revealed that PHF6 bound to the promoters of a subset of neuronal immediate-early genes (IEGs) and regulate their expression levels. hunger state. Examination of differentially expressed genes under fed and fasted conditions in wild type and PHF6 conditional knockout mice.我们的研究发现，PHF6可结合至部分神经元即刻早期基因（neuronal immediate-early genes, IEGs）的启动子区域，并在饥饿状态下调控其表达水平。本研究对野生型及PHF6条件性基因敲除小鼠在进食与禁食状态下的差异表达基因进行了检测。