ABCC1,4,5 transport APAP-Cys,APAP-Mer from cytosol to extracellular region

The ATP-binding cassette sub-family C member transporters (ABCCs, aka multidrug resistance-associated proteins, MRPs) mediate the export of organic anions and drugs from cells. Induction of ABCC expression after APAP-induced liver failure may represent a compensatory mechanism of damaged hepatocytes to reduce accumulation of potentially toxic compounds. ABCC1, 4 and 5 are thought to efflux the cysteine- and mercapto-conjugates of paracetamol (APAP-Cys and APAP-Mer respectively) from hepatocytes (Barnes et al. 2007).

ATP结合袋子亚家族C成员转运蛋白（ABCCs，亦称多药耐药相关蛋白，MRPs）介导有机阴离子和药物从细胞中的排出。在APAP（对乙酰氨基酚）诱导的肝衰竭后诱导ABCC表达可能代表了受损肝细胞的补偿机制，以减少潜在有毒化合物的积累。ABCC1、4和5被认为能将帕拉цет米尔的半胱氨酸和巯基共轭物（分别称为APAP-Cys和APAP-Mer）从肝细胞中泵出（Barnes等，2007年）。