MicroRNA Expression Profiling of Hypoxic Cardiomyocytes Treated with Oxygenated Perfluorocarbon Nanobubbles Invitro.

MicroRNAs (miRNAs) are non-coding RNAs responsible for post-transcriptional gene expression regulation through interaction with messenger RNAs (mRNAs). The dataset is the miRNA expression profile of the in-vitro study performed to evaluate oxygenated perfluorocarbon nanobubbles' ability to protect the cardiomyocytes from hypoxia-related cardiomyocytic injury. The results were compared with cardiomyocytes in phosphate-buffered saline (PBS) under normoxia conditions and also after hypoxia (5% O2) treatment. The dataset describes miRNA profiling of cardiomyocytes when treated with and without perfluorocarbon nanobubbles. The data represents the list of miRNA assay and the fold changes. The cardiomyocytes were subjected to severe hypoxia with and without perfluorocarbon nanobubbles for 3.5 hours, and the miRNA expression profiling was performed. This is to mimic acute myocardial infarction milieu, invitro. The miRNA data is especially useful for researchers working on novel biomarkers in acute myocardial infarction or in heart failure/ cardiovascular diseases. The function of the perfluorocarbon nanobubbles could be further enhanced by vascular endothelial growth factor (VEGF) or RGD conjugations. *Global normalization value that is >100 is indicated in yellow in the dataset.