Suppression of brittle bristle and cuticle defects by overexpression of Dmp8/TTDA in heteroallelic Dmp52 mutant flies.

aThe percentages represent the heteroallelic flies without the balancers for the 3rd chromosome. +/+; mrn5/EP3605 flies are semi-lethal and the presence of the transgene increases the their survival rate and rescues their bristles and cuticle defects. A partial rescue of fertility is also observed (Figure 1C). The number in parenthesis is the number of heteroallelic individuals without balancers divided by the total number of flies expected for full complementation. The crosses to obtain heteroallelic +/+; mrn5/EP3605 flies were independent of transgenic fly crosses.bThe percentage represents the number of adult flies with brittle bristles and cuticle defects observed in heteroallelic flies with and without the transgene. The number in parenthesis is the number of heteroallelic individuals with the mutant phenotype divided by the number of total heteroallelic flies that survive without the balancers. Brittle bristles and cuticle deformation phenotypes are shown in Figure 1D.