Genome-wide CRISPR screens in LKB1-null and WT cells in 2D and spheroid culture

NIAID Data Ecosystem2026-05-10 收录

CRISPRi筛选

LKB1依赖性

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP464040 数据链接链接失效反馈

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资源简介：

Genome-wide CRISPR screens in A549 LKB1-null and WT cells in 2D and spheroid culture.

创建时间：

2025-10-01

raw data for main figures.xlsx

CRISPRi筛选

功能基因组学

data used to create main figures for: Park et. al., Efficient prioritization of CRISPR screen hits by accounting for targeting efficiency of guide RNA, BMC Biol, 2023.

Figshare2023-01-28 更新70

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

NIAID Data Ecosystem30

Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies. Mair et al.

干细胞鉴定

CRISPRi筛选

Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms,

NIAID Data Ecosystem20

Genome-wide CRISPR/Cas9 loss-of-function screen for prostate cancer cell line. Genome-wide CRISPR/Cas9 loss-of-function screen for prostate cancer cell line

CRISPRi筛选

前列腺癌联合治疗

Prostate cancer (PCa) is the most frequently diagnosed malignancy in men worldwide. Epigenetic regulation has been recognized as a main mechanism of cancer evolution. PRMT5 is the major type II protei

NIAID Data Ecosystem30

Mitochondrial and ER membrane protein trafficking CRISPR screens

线粒体/内质网蛋白运输

CRISPRi筛选

The trafficking of specific protein cohorts to the correct subcellular location at the correct time is essential for every signaling and regulatory process in biology. Gene perturbation screens could

NIAID Data Ecosystem30

Genome-wide CRISPR screens in LKB1-null and WT cells in 2D and spheroid culture

资源简介：

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