Structure of rat neuronal nitric oxide synthase R349A heme domain in complex with 4-methyl-6-(3-(methylamino)prop-1-yn-1-yl)pyridin-2-amine
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Structure of rat neuronal nitric oxide synthase R349A heme domain in complex with 4-methyl-6-(3-(methylamino)prop-1-yn-1-yl)pyridin-2-amine Descriptor: 4-methyl-6-[3-(methylamino)prop-1-yn-1-yl]pyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... Authors: Li, H, Poulos, T.L. Deposit date: 2022-01-31 Release date: 2022-07-13 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.8177 Å) Cite: 2-Aminopyridines with a shortened amino sidechain as potent, selective, and highly permeable human neuronal nitric oxide synthase inhibitors. Bioorg.Med.Chem., 69, 2022
大鼠神经元型一氧化氮合酶R349A血红素结构域与4-甲基-6-(3-(甲氨基)丙-1-炔-1-基)吡啶-2-胺结合的晶体结构
配体信息：4-甲基-6-[3-(甲氨基)丙-1-炔-1-基]吡啶-2-胺、5,6,7,8-四氢生物蝶呤、乙酸根离子……
作者：Li, H、Poulos, T.L.
提交日期：2022-01-31
发布日期：2022-07-13
最后修改日期：2023-10-18
实验方法：X射线衍射（分辨率1.8177埃）
引用文献：《带有缩短氨基侧链的2-氨基吡啶类强效、选择性且高渗透性的人神经元型一氧化氮合酶抑制剂》，Bioorg.Med.Chem., 69, 2022
创建时间：
2022-01-31
