Structure of HIV-1 integrase core domain in complex with sucrose (PDB ID 3L3V): data

This data collection represents the highest resolution crystal structure of the IN core domain to date, and also presents a crystal structure of the IN core domain in complex with sucrose which is bound at the dimer interface in a region that has previously been reported to bind integrase inhibitors. HIV integrase (IN) is an essential enzyme in HIV replication and an important target for drug design. IN has been shown to interact with a number of cellular and viral proteins during the integration process. Disruption of these important interactions could provide a mechanism for allosteric inhibition of IN.