Oligosymptomatic long-term carriers of SARS-CoV-2 display impaired innate resistance but increased high-affinity anti-Spike antibodies. Montes-Cobos et al.

Our aim was to compare the immune responses of mildly-symptomatic COVID-19 patients with regular course of infection to those of patients with persistent SARS-CoV-2 infection. These set of data was obtained from plasma and PBMCs purified from healthy human individuals (HC) and COVID-19 patients with either a short infection period (until 21 days after symptom onset, NP) or with long-term infection (detectable SARS-CoV-2 RNA by qRT-PCR in nasopharynx for longer than 21 days after symptoms onset, P). The data represent a set of plasma cytokines and flow cytometry imunophenotyping data obtained from frozen plasma and PBMCs from the refered study subjects. We observed significant diferents in several of the analyzed parameters between the study groups, indicating distinct immune responses defining the group of olygosymptomatic long-term infected patients.本研究旨在对比感染进程规律的轻症新型冠状病毒肺炎（COVID-19）患者与持续性严重急性呼吸综合征冠状病毒2（SARS-CoV-2）感染患者的免疫应答差异。本数据集采集自健康对照（Healthy Control, HC）及两类COVID-19患者的血浆与纯化外周血单个核细胞（Peripheral Blood Mononuclear Cells, PBMCs）：一类为感染周期较短的患者（症状出现后21天内，NP组），另一类为长期感染患者（症状出现后21天以上，鼻咽部样本经实时定量逆转录聚合酶链反应（quantitative real-time reverse transcription polymerase chain reaction, qRT-PCR）仍可检出SARS-CoV-2 RNA，P组）。本数据集包含来自上述研究对象的冻存血浆与外周血单个核细胞的血浆细胞因子检测数据及流式细胞术免疫表型分析数据。本研究在各组间的多项分析参数中观察到显著差异，表明寡症状长期感染患者具有独特的免疫应答特征。