PC is hydrolyzed to 1-acyl LPC by PLA2[6]

At the endoplasmic reticulum (ER) membrane, phosphatidylcholine (PC) is hydrolyzed, and has one of its acyl chains cleaved off, by a membrane-associated phospholipase A2 to form 1-acyl lysophosphatidylcholine (LPC). The phospholipases are either phospholipase A2 group II alpha (PLA2G2A) (Seihamer et al. 1989, Singer et al. 2002), cytosolic phospholipase A2 group IV gamma (PLA2G4C) (Yamashita et al. 2005, Pickard et al. 1999, Ghomashchi et al. 2010, Yamashita et al. 2009), or calcium-independent phospholipase A2-gamma (PNPLA8) (Murakami et al. 2005, Underwood et al. 1998).

在内质网（ER）膜上，磷脂酰胆碱（PC）被膜结合的磷脂酶A2水解，并切断其一个酰基链，形成1-酰基溶血磷脂酰胆碱（LPC）。磷脂酶包括磷脂酶A2第II组α型（PLA2G2A）（Seihamer等，1989，Singer等，2002），细胞质磷脂酶A2第IV组γ型（PLA2G4C）（Yamashita等，2005，Pickard等，1999，Ghomashchi等，2010，Yamashita等，2009）或钙非依赖性磷脂酶A2-γ（PNPLA8）（Murakami等，2005，Underwood等，1998）。