Crystal structure of Keap1 in complex with a small molecule inhibitor, KMN003

Crystal structure of Keap1 in complex with a small molecule inhibitor, KMN003 Descriptor: 4-[1,4-bis[(4-ethoxyphenyl)sulfonylamino]naphthalen-2-yl]butanoic acid, FORMIC ACID, Kelch-like ECH-associated protein 1 Authors: Ishida, H, Osawa, M. Deposit date: 2025-06-10 Release date: 2025-11-12 Last modified: 2026-01-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: KMN003 activates Nrf2 via disruption of the Keap1-Nrf2 interaction and p38-dependent transcriptional regulation. Cell Signal., 137, 2026与小分子抑制剂KMN003结合的Keap1（Kelch样ECH相关蛋白1）晶体结构 结构描述：4-[1,4-双[(4-乙氧基苯基)磺酰氨基]萘-2-基]丁酸、甲酸 作者：Ishida, H、Osawa, M. 存储日期：2025-06-10 发布日期：2025-11-12 最后修改日期：2026-01-21 实验方法：X射线衍射（分辨率1.7 Å） 引用文献：KMN003通过破坏Keap1-Nrf2相互作用及p38依赖的转录调控激活Nrf2。《细胞信号传导》，137卷，2026年。