MiR-30a-5p frequently downregulated in prostate cancer inhibits cell proliferation via targeting PCLAF
收藏Taylor & Francis Group2025-10-24 更新2026-04-16 收录
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https://tandf.figshare.com/articles/dataset/MiR-30a-5p_frequently_downregulated_in_prostate_cancer_inhibits_cell_proliferation_via_targeting_PCLAF/7618529/2
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资源简介：
MicroRNAs (miRNAs) have vastly expanded our view of RNA world in intracellular signal regulating networks. Here, we functionally characterized a normally highly expressed miRNA, miR-30a-5p (MIMAT0000087), which exhibits downregulated expression profiles in prostate cancer samples. MiR-30a-5p knockdown and overexpression in PC-3 cell line alters cell proliferation supporting a tumour suppressor role. We also discovered that PCLAF is the direct target of miR-30a-5p. Notably, PC-3 cell proliferation is inhibited by miR-30a-5p/PCLAF axis. miR-30a-5p represents a novel molecule of functionally important miRNAs which may shed light on the novel therapeutic targets for prostate cancer.
提供机构：
Wang, Shuiliang; Zhao, Hu; Wu, Weizhen; Zhu, Hehuan; Zhang, Shenhang; Tang, Minying; Tan, Jianming; Deng, Zhen; Zhang, Wei; Lai, Xiaofeng
创建时间：
2019-05-10
