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Chemical Inhibition of H3K27me3 demethylases during B cell differentiation

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NIAID Data Ecosystem2026-03-13 收录
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To understand the role of the H3K27me3 demethylases, UTX and JMJD3, in B cell differentiation. Naïve B cells were cultures ex vivo with LPS, IL-2,IL-5 in the presence of DMSO or GSK-J4, UTX/JMJD3 inhibitor. Plasmablasts and activated B cells were magnetically enriched after 3 days of culture. RNAseq on B cells treated with GSK-J4 or DMSO

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2022-01-04
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