Non-canonical (A) and canonical (B) modules.

The color coding of the bigger nodes represent log fold-changes of significantly DEGs: blue represents down-regulation and red up-regulation of the genes in MDA-MB-231 compared to MCF-7. The smaller nodes where introduced by the Steiner tree analysis to ensure connectivity of the differentially regulated WNT modules; the smaller nodes with the yellow dots depict Steiner nodes which were confirmed by the modules in the validation dataset. The directed edges represent controlling interactions.