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FoxA1 directs the lineage and immunosuppressive properties of FoxA1+ regulatory T cells in EAE and MS

ChEBI2014-02-16 更新2026-07-21 收录

自身免疫疾病机制

调节性T细胞功能

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https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-GEOD-54490 数据链接链接失效反馈

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FoxA1 directs the lineage and immunosuppressive properties of FoxA1+ regulatory T cells in EAE and MS

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创建时间：

2014-02-16

自身免疫疾病机制

细胞表型鉴定

Pathogenic T helper cells (Th cells) that respond to self-antigen cannot be easily distinguished from beneficial Th cells. These cells can generate systemic autoimmune disease in response to widely-ex

NIAID Data Ecosystem90

H3K27me3 ChIP-seq of naïve CD4 T cells. H3K27me3 ChIP-seq of naïve CD4 T cells

细胞表观遗传学

自身免疫疾病机制

Differentiation and activation of T cells require the activity of numerous histone lysine methyltransferases (HMT) that control the transcriptional T cell output. One of the most potent regulators of

NIAID Data Ecosystem60

Supporting data for "The role of AIM2 inflammasome in Systemic Lupus Erythematosus"

自身免疫疾病机制

炎症小体功能

Systemic Lupus Erythematosus is a chronic autoimmune condition in which the body mistakenly attacks itself. It’s aetiopathogenesis is highly complex. Increasing evidence suggests that the innate immun

DataCite Commons2021-09-15 更新50

Foxp3-dependent and -independent functions of peripherally-induced Treg cells [09748]

调节性T细胞功能

免疫耐受机制

Regulatory T (Treg) cells expressing the lineage-defining transcription factor Foxp3 are essential for the maintenance of immune tolerance. Foxp3 expression can be induced in a subset of developing se

NIAID Data Ecosystem60

Genetically-driven target tissue over-expression of CD40: A novel mechanism in autoimmune disease

自身免疫疾病机制

免疫病理学

The CD40 gene, an important immune regulatory gene, is also expressed and functional on non-myeloid derived cells, many of which are targets for tissue specific autoimmune diseases, including d thyroi

NIAID Data Ecosystem50

FoxA1 directs the lineage and immunosuppressive properties of FoxA1+ regulatory T cells in EAE and MS

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