Young infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2. Goenka et al

Complete dataset associated with manuscript "Young infants exhibit robust functional antibody responses and restrained IFN-γ production to SARS-CoV-2. Goenka et al". All samples arranged by their nomenclature in the paper (infants I1-4; mothers M1-3; fathers F1-4; PCR-confirmed adult controls C1-10; pre-pandemic serum samples PP1-PP9). The folder "ELISA serum and saliva" contains original OD600nm data, and relative units for LIPS (Luciferase ImmunoPrecipitation System) assays as indicated, and corresponds to Fig. 1A-D & Fig. S1 in manuscript. The folder "Neutralisation" contains data describing percentage of SARS-CoV-2 infected cells relative to control wells containing virus only (no sera), and corresponds to Fig. 1E-F & Fig. S2. The folder "ELISpot" contains SFU/million PBMC data (after background unstimulated subtraction) and corresponds to Fig. 2A and S3A-B. The folder "Intracellular Cytokine Staining FCS files" contains original FACS acquisition data (with compensation controls) in folders per each experiment and corresponds to Fig. 2B-F and Fig. S3C-F.本数据集配套于论文《幼龄婴儿对新型冠状病毒（SARS-CoV-2）展现出强劲的功能性抗体应答与受抑制的干扰素-γ（Interferon-γ，IFN-γ）生成》（Goenka等人），完整收录该研究的全部关联数据。所有样本均按照论文中的命名规则整理：婴儿组I1-4、母亲组M1-3、父亲组F1-4、经PCR确认的成年对照组C1-10，以及大流行前血清样本PP1-PP9。名为“ELISA血清与唾液”的文件夹收录原始OD600nm检测数据，以及标注的荧光素酶免疫沉淀系统（Luciferase ImmunoPrecipitation System，LIPS）检测相对单位，对应论文中的图1A-D及补充图S1。名为“中和实验”的文件夹收录以仅含病毒（无血清）对照孔为基准的SARS-CoV-2感染细胞百分比数据，对应论文中的图1E-F及补充图S2。名为“ELISpot”的文件夹收录经背景（未刺激组）扣除后的每百万外周血单个核细胞（Peripheral Blood Mononuclear Cell，PBMC）斑点形成单位（Spot Forming Unit，SFU）数据，对应论文中的图2A及补充图S3A-B。名为“细胞内细胞因子染色FCS文件”的文件夹按单次实验分组收录原始流式细胞术采集数据（含补偿对照），对应论文中的图2B-F及补充图S3C-F。