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KAT6A impairs PARP1 trapping of PARP inhibitors by the noncatalytic function of KAT6A in ovarian cancer

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下载链接:
https://www.ncbi.nlm.nih.gov/sra/SRP411821
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资源简介:
PARP inhibitor (PARPi) resistance impedes the treatment of ovarian cancer in clinical practice. However, the mechanisms by which cancer cells overcome PARPi treatment remain obscure. Here, we showed that high level of KAT6A promotes PARPi resistance in ovarian cancer independent on its catalytic functions.
创建时间:
2022-12-07
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