Alloimmune responses of humanized mice to human pluripotent stem cell therapeutics
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
下载链接：
http://data.iscr.ac.cn/Article?id=bfa506441c280c4281c3be7c12105181
下载链接
链接失效反馈官方服务：
资源简介：
Temporal tracking of transcriptional changes of human T cells in humanized mice. In this experiment, we studied the ability of immunodeficient NOD-SCID IL2Rgamma-null mice with reconstituted human immune systems to recapitulate graft vs host disease against engrafted tissues. Interestingly, we found that the mice failed to fully reject engrafted tissues, and evaluation of T-cells isolated from grafts demonstrated decreased expression of inflammatory cytokines. We hypothesized this phenotype was due to the devlopment of an "exhausted phenotype." To assess this, we tracked the development of human T-cells in these mice beginning 8 weeks after engraftment of human immune components, and monitored their transcriptional profiles to assess for markers of anergy, exhaustion, and immune activation.
提供机构：
Stanford University School of Medicine
创建时间：
2022-02-20
