Spatial Transcriptomic analysis (GeoMx) of SNc ventral tier dopamine cells in control and PD subjects

The repository includes Spatial Transcriptomic datasets generated by Nanostring GeoMx (Hu WTA) analysis of SNc ventral tier TH+ cells from Controls (n=10) and Early Parkinson's Disease subjects (n=8). A total 73 Regions of Interest were analysed. The processed counts and metadata are provided as an R Seurat object (geomx_110124_seurat.v5.Rdata). In addition raw DCC files are provided (DCC_Rademacher_2024.zip). The data was generated as part of the study Rademacher et al.,"Chronic hyperactivation of midbrain dopamine neurons causes preferential dopamine neuron degeneration", 2024.

This research was funded in whole or in part by Aligning Science Across Parkinson’s (ASAP-020529) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF). For the purpose of open access, the author has applied a CC BY 4.0 public copyright license to all Author Accepted Manuscripts arising from this submission.