Role of Gpnmb in response to PFF-induced spreading alpha-synucleinopathy. Role of Gpnmb in response to PFF-induced spreading alpha-synucleinopathy

Effect of Gpnmb knockout on development of differential expression in PFF-aSyn model was studied. The "sample_id" sample characteristic is a sample identifier internal to Genentech. The ID of this project in Genentech's ExpressionPlot database is PRJ0036142 Overall design: RNA from ipsilateral whole striatum, midbrain or brainstem of mixed-sex (but balanced) GPNMB WT or knockout mice 60 or 90 days after injection with either aSyn pre-formed fibrils (PFF) or monomer (mono) control.