Carvacrol alleviates endoplasmic reticulum stress and inflammation induced by lipopolysaccharide by enhancing endoplasmic reticulum autophagy in dairy mammary epithelial cells.

Carvacrol (CAV) exhibits the capacity to augment endoplasmic reticulum autophagy (ER-phagy) in bovine mammary epithelial cells, mitigating endoplasmic reticulum stress (ER-stress) and inflammatory responses, thereby contributing positively to the amelioration of bovine mastitis. By Yang et al. In this paper, the effect of natural plant monomer CAV on enhancing ER-phagy and alleviating ER-stress and inflammation in mammary epithelial cells of dairy cows was discussed in the treatment of mastitis. Through in vivo and in vitro experiments, we found that ER-stress in mastitis tissue was significantly up-regulated, and the ER-phagy pathway, a key pathway that regulates cell homeostasis, was impaired. And CAV was proved to enhance endoplasmic reticulum autophagy. We found that there is a correlation between ER-phagy and ER-stress in dairy mammary epithelial cells, which may be an important direction for the treatment of dairy mastitis.香芹酚（Carvacrol, CAV）可增强牛乳腺上皮细胞中的内质网自噬（endoplasmic reticulum autophagy, ER-phagy），缓解内质网应激（endoplasmic reticulum stress, ER-stress）与炎症反应，进而对奶牛乳腺炎的改善起到积极作用。本研究由Yang等人完成，文中探讨了天然植物单体香芹酚（CAV）在奶牛乳腺炎治疗中，增强奶牛乳腺上皮细胞内质网自噬、减轻内质网应激与炎症的效应。通过体内外实验，研究团队发现乳腺炎组织中的内质网应激水平显著上调，而调控细胞稳态的关键通路——内质网自噬通路出现功能受损。实验证实香芹酚（CAV）可增强内质网自噬。此外，研究团队发现奶牛乳腺上皮细胞中的内质网自噬与内质网应激存在相关性，这或许可为奶牛乳腺炎的治疗提供重要研究方向。