Crystal structure of mutant beta-K167T tryptophan synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the alpha-site, cesium ion at the metal coordination site, and 2-aminophenol quinonoid (1D0) at the beta-site

Crystal structure of mutant beta-K167T tryptophan synthase in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the alpha-site, cesium ion at the metal coordination site, and 2-aminophenol quinonoid (1D0) at the beta-site Descriptor: (2E)-2-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)imino]-3-[(2-hydroxyphenyl)amino]propanoic acid, 1,2-ETHANEDIOL, 2-({[4-(TRIFLUOROMETHOXY)PHENYL]SULFONYL}AMINO)ETHYL DIHYDROGEN PHOSPHATE, ... Authors: Hilario, E, Dunn, M.F, Mueller, L.J, Fan, L. Deposit date: 2018-06-20 Release date: 2019-06-26 Last modified: 2023-10-11 Method: X-RAY DIFFRACTION (1.791 Å) Cite: Tryptophan synthase Q114A mutant in complex with inhibitor N-(4'-trifluoromethoxybenzenesulfonyl)-2-amino-1-ethylphosphate (F9F) at the alpha-site, aminoacrylate (P1T) at the beta site, and cesium ion at the metal coordination site. To be Published

本数据集包含突变体β-K167T色氨酸合酶（tryptophan synthase）的晶体结构，该酶与以下配体形成复合物：α位点（alpha-site）的抑制剂N-(4'-三氟甲氧基苯磺酰基)-2-氨基-1-乙基磷酸（F9F）、金属配位位点的铯离子，以及β位点（beta-site）的2-氨基苯酚醌型中间体（1D0）。描述物包括：(2E)-2-[({3-羟基-2-甲基-5-[(膦酰氧基)甲基]吡啶-4-基}甲基)亚氨基]-3-[(2-羟基苯基)氨基]丙酸、1,2-乙二醇、2-({[4-(三氟甲氧基)苯基]磺酰基}氨基)乙基二氢磷酸酯……。作者：Hilario, E、Dunn, M.F、Mueller, L.J、Fan, L。存档日期：2018-06-20；发布日期：2019-06-26；最后修改日期：2023-10-11。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.791 Å）。引用文献：结合α位点抑制剂N-(4'-三氟甲氧基苯磺酰基)-2-氨基-1-乙基磷酸（F9F）、β位点氨基丙烯酸酯（P1T）以及金属配位位点铯离子的色氨酸合酶Q114A突变体，待发表。